Outline

Faculty

SHIMA Fumi

Laboratory

KUID

Position

Professor

Research Field

Molecular Biology, Biochemistry, Structual Biology, Drug Discovery Science, Physiology

Profile

Educational Background

M.D., School of Medicine, Kobe University, 1991

Ph.D., Graduate School of Medicine, Kobe University, 1998

Current Position

Professor, Advanced Medical Science Area, Graduate School of Science, Technology and Innovation, Kobe University
Professor,Dep. Mol. & Cell. Biol., Graduate School of Medicine, Kobe University(supplementary assignment)

Research Career

2016-:Professor, Advanced Medical Science Area, Graduate School of Science, Technology and Innovation, Kobe University: screenings for novel Ras/MAPK signaling inhibitors are on going.
2015-2016:Professor, Dep. Mol. & Cell. Biol., Graduate School of Medicine Kobe University; kick off of the project " screening for novel Ras/MAPK signaling inhibitors"
2011-2015: Associate Professor, Dep. Mol. & Cell. Biol., Graduate School of Medicine, Kobe University ; collaborative development for lead compound optimization with the domestic pharmaceutical company
2010-2011:Senior Assistant Professor, Dep. Mol. & Cell. Biol., Graduate School of Medicine, Kobe University; collaborative development of the lead compounds with KNC laboratories co., Ltd. ; patent application and derivation to the domestic pharmaceutical company
2002-2010:Assistant Professor, Dep. Mol. & Cell. Biol., Graduate School of Medicine, Kobe University; Discovery of the drug-binding pocket of Ras protein, leading to the kick-off of the project "in slilico anti-cancer drug screening targeting Ras"
2000-2002:Instructor, Dep. Physiol. II, School of Medicine, Kobe University; studies on structural biology of Ras family small GTPases by X-ray crystallography
1998-2000:JSPS Postdoctoral Research Fellow, Dep. Physiol. II, School of Medicine, Kobe University; studies on the molecular mechanism for budding yeast adenyly cyclase activation by a homologue of mammalian ras oncogene product Ras2
1998:Ph.D., School of Medicine, Kobe University, Academic Appointments

Message

Our goal is the anti-cancer drug development targeting Ras/MAPK signaling pathways closely relatd to formation and development of cancers. Since oncogene products including Ras play crucial roles for survival of cancer cells and tissues, inhibitors against these gene products are suggested to be potent and promising candidats for development of anti-cancer drugs. In our labolatory, screenings for novel Ras/MAPK signaling inhibitors are on going, by using biochemical and molecular biological approaches, furthermore, structure biological (collabolative studies with Kobe University Graduate School of Medicin and Japan Synchrotron Radiation Res. Inst.) and computational approaches (collabolative studies with Graduate School of System Informatics, Kobe University and Inst. of Physical and Chemical Research).

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